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KMID : 0882419760190111016
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Korean Journal of Medicine
1976 Volume.19 No. 11 p.1016 ~ p.1025
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Bleeding Tendency and Coagulative Properties of Cancer
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Hong Sung-Woon
Kim Byoung-Kook
Lee Jung-Sang
Lee Mun-Ho
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Abstract
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A comprehensive studies of the hemostatic and coagulation mechanisms in 93 patients with disseminated malignancy was carried out. Significant laboratory abnormalities were found in the patients. Some of patients was the "hypercoagulable state". This included high level of fibrinogen and thrombocytosis. But 25% of patients was hypocoagulable state. Fibrinolysis was confirmed 15 patients by partial thromboplastin time, euglobulin-lysis time, thrombin time and protamine-gelation test. The data suggest that, patients with cancer have an alteration in the hemostatic level of control with increased of both clotting factors and their inhibitors resulting in a more easily disturbed balance between opposing hemostatic forces. Clinical thrombosis or bleeding may follow.
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KEYWORD
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